|
KMID : 0811720180220030301
|
|
Korean Journal of Physiology & Pharmacology
2018 Volume.22 No. 3 p.301 ~ p.309
|
|
|
Atorvastatin pretreatment attenuates kainic acid-induced hippocampal neuronal death via regulation of lipocalin-2-associated neuroinflammation
|
|
Jin Zhen
Jung Yo-Han
Yi Chin-Ok
Lee Jong-Youl
Jeong Eun-Ae
Lee Jung-Eun
Park Ki-Jong
Kwon Oh-Young
Lim Byeong-Hoon
Roh Gu-Seob
|
|
|
Abstract
|
|
|
|
Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism for its protective effect in kainic acid (KA)-induced seizures. Here, we investigated the protective effects of atorvastatin pretreatment on KA-induced neuroinflammation and hippocampal cell death. Mice were treated via intragastric administration of atorvastatin for 7 days, injected with KA, and then sacrificed after 24 h. We observed that atorvastatin pretreatment reduced KA-induced seizure activity, hippocampal cell death, and neuroinflammation. Atorvastatin pretreatment also inhibited KA-induced lipocalin-2 expression in the hippocampus and attenuated KA-induced hippocampal cyclooxygenase-2 expression and glial activation. Moreover, AKT phosphorylation in KA-treated hippocampus was inhibited by atorvastatin pretreatment. These findings suggest that atorvastatin pretreatment may protect hippocampal neurons during seizures by controlling lipocalin-2-associated neuroinflammation.
|
|
|
KEYWORD
|
|
|
Atorvastatin, Hippocampal cell death, Kainic acid, Lipocalin-2, Seizures
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|